What are the multisociety guidelines for aortic stenosis (AS)?

Updated: May 07, 2019
  • Author: Xiushui (Mike) Ren, MD; Chief Editor: Terrence X O'Brien, MD, MS, FACC  more...
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Answer

2014 AHA/ACC updated guidelines for the management of valvular heart disease

The 2014 AHA/ACC updated guidelines recommendations for AS include the following [6, 54] :

  • Patients with signs or symptoms of AS or a bicuspid aortic valve should be evaluated with transthoracic echocardiography (TTE); selected patients with stage D2 AS may be evaluated with low-dose dobutamine stress testing

  • Hypertension should be treated in patients at risk for, and with, asymptomatic AS

  • Surgical aortic valve replacement (AVR) is recommended for patients who meet an indication for AVR  as summarized below, in Table 3.

Table 3. Indications for Aortic Valve Replacement in Aortic Stenosis (Open Table in a new window)

Indication

Class

Symptomatic severe high-gradient AS (Stage D1)

I

Asymptomatic severe AS (Stage C2) with and LVEF <50%

I

Severe AS (Stage C or D) undergoing other cardiac surgery 

I

Asymptomatic, very severe AS (Stage C1, aortic velocity ≥5.0 m/s) and low surgical risk

IIa
Asymptomatic, severe AS (Stage C1) and decreased expercise tolerance or an exercise fall in blood pressure IIa
Symptomatic severe low flow/low gradient AS with reduced LVEF (Stage D2) with a low-dose dobutamine stress study with aortic velocity ≥4.0 m/s with a value are ≤1.0 cmat any dobutamine dose IIa
Symptomatic severe low flow/low gradient AS (Stage D3) who are normotensive and have an LVEF ≥50% if clinical, hemodynamic and anatomic data support valve obstruction as the most likely cause of symptoms IIa
Moderate AS (Stage B) who are undergoing other cardiac surgery IIa
Asymptomatic  severe AS (Stage C1) with rapid disease progression and low surgical risk IIb

2017 AHA/ACC focused updates for the management of patients with valvular heart disease

In 2017, the AHA/ACC eleased a focused update to their 2014 guidelines for the management of patients with valvular heart disease (VHD). [52]  Their updated recommendations for the treatment of aortic stenosis are summarized below.

Surgical AVR is recommended for symptomatic patients with severe aortic stenosis (Stage D) and asymptomatic patients with severe aortic stenosis (Stage C) who meet an indication for AVR when the surgical risk is low or intermediate.

Surgical AVR or TAVR is recommended for symptomatic patients with severe aortic stenosis (Stage D) and high risk for surgical AVR, depending on patient-specific procedural risks, values, and preferences.

TAVR is recommended for symptomatic patients with severe aortic stenosis (Stage D) and a prohibitive risk for surgical AVR who have a predicted post-TAVR survival greater than 12 months.

TAVR is a reasonable alternative to surgical AVR for symptomatic patients with severe aortic stenosis (Stage D) and an intermediate surgical risk, depending on patient-specific procedural risks, values, and preferences.

2017 multisociety appropriate use criteria for the treatment of aortic stenosis

In 2017, the first document to address appropriate use criteria for the treatment of severe aortic stenosis was released as a collaborative effort by the American College of Cardiology (ACC) Appropriate Use Criteria Task Force, American Association for Thoracic Surgery (AATS), American Heart Association (AHA), American Society of Echocardiography (ASE), European Association for Cardio-Thoracic Surgery (EACTS), Heart Valve Society (HVS), Society of Cardiovascular Anesthesiologists (SCA), Society for Cardiovascular Angiography and Interventions (SCAI), Society of Cardiovascular Computed Tomography (SCCT), Society for Cardiovascular Magnetic Resonance (SCMR), and Society of Thoracic Surgeons (STS). [50, 51]  Eight key recommendations are outlined below.

Asymptomatic patients with high-gradient severe aortic stenosis

No intervention is appropriate or intervention may be considered for those with a left ventricular ejection fraction (LVEF) of at least 50%, Vmax 4.0-4.9 m/s, negative exercise stress, and no predictors of rapid progression.

Intervention is appropriate or no intervention may be considered for those with a high-risk profession or lifestyle and low surgical risk, or for those with a predictor of rapid progression. Intervention is appropriate for those with very severe aortic stenosis (Vmax ≥5.0 m/s or mean gradient ≥60 mmHg) and low surgical risk, and it is appropriate or may be considered for those at intermediate or high surgical risk.

Intervention is appropriate for patients with an abnormal exercise test, an LVEF below 50%, or when undergoing another cardiac surgical procedure.

Low-flow (LF) low-gradient (LG) severe aortic stenosis and reduced LVEF (< 50%)

Intervention is appropriate for patients with LFLG severe aortic stenosis and an LVEF of 20-49% with flow reserve on low-dose dobutamine stress echocardiography (DSE); intervention is appropriate or balloon aortic valvotomy (BAV) or no intervention may be considered for patients with no flow reserve, but with a very calcified aortic valve suggestive of truly severe aortic stenosis.

For patients with an LVEF below 20%, intervention is appropriate or BAV may be considered for patients with severe high-gradient aortic stenosis, or for patients with LFLG aortic stenosis and flow reserve on DSE.

Intervention is inappropriate for patients with pseudo-severe aortic stenosis; or for patients with an LVEF below 20%, mean gradient less than 20 mmHg, and no flow reserve on DSE.

LG severe aortic stenosis and preserved LVEF (≥50%)

Intervention is appropriate for patients with severe aortic valve calcification, symptoms referable to aortic stenosis, and the following:

  • LFLG severe aortic stenosis 
  • Normal flow (NF) LG aortic stenosis

Symptomatic severe aortic stenosis and high or extreme surgical risk

For symptomatic patients with an STS predicted risk of mortality (STS-PROM) of 8-15% due to multiple comorbidities, transcatheter aortic valve replacement (TAVR) is appropriate and surgical AVR (SAVR) may be reasonable if the anticipated life expectancy is greater than 1 year; neither TAVR nor SAVR is reasonable if the anticipated life expectancy is less than 1 year.

For patients with an STS-PROM above 15% due to multiple comorbidities, TAVR is appropriate if the health status appears influenced more by aortic stenosis than by comorbidities and the anticipated life expectancy is longer than 1 year.

For patients with an STS-PROM of 8-15% due to frailty with symptoms of fatigue but no chest pain, syncope, or shortness of breath, TAVR is appropriate if B-type natriuretic peptide (BNP) is elevated or if the aortic stenosis is very severe (Vmax ≥5 m/s).

TAVR is appropriate for patients with severe symptomatic aortic stenosis and porcelain aorta or hostile chest.

Symptomatic severe high-gradient aortic stenosis with associated coronary artery disease (CAD)

For patients with 1- or 2-vessel CAD:

  • SAVR plus coronary artery bypass grafting (CABG) is appropriate for low, intermediate, or high surgical risk;
  • TAVR plus percutaneous coronary intervention (PCI) is appropriate for patients at intermediate or high surgical risk; and
  • SAVR plus PCI may be appropriate in the absence of proximal left anterior descending artery (LAD) involvement

For patients with 3-vessel CAD:

  • SAVR plus CABG is appropriate for low, intermediate, or high surgical risk and regardless of the SYNTAX (Synergy between percutaneous coronary intervention with Taxus and Cardiac Surgery) score; and
  • TAVR plus PCI is appropriate for patients at intermediate or high surgical risk and a SYNTAX score below 22

For patients with left main CAD:

  • SAVR plus CABG is appropriate for low, intermediate, or high surgical risk and regardless of the SYNTAX score;
  • TAVR plus PCI is appropriate for patients at intermediate or high surgical risk and a SYNTAX score below 33; and
  • TAVR plus PCI may be appropriate for patients at intermediate or high surgical risk and a SYNTAX score of at least 33

Symptomatic severe aortic stenosis with another valve or ascending aorta pathology

SAVR plus surgical mitral intervention is appropriate for patients at low, intermediate, or high surgical risk in the settings of severe primary mitral regurgitation (MR) or severe secondary MR. Either SAVR plus surgical mitral intervention or TAVR plus percutaneous balloon mitral valvotomy (PBMV) is appropriate in the setting of severe rheumatic MS with no contraindication to PMBV and high surgical risk.

SAVR plus surgical tricuspid valve intervention is appropriate for patients at intermediate surgical risk with severe secondary tricuspid regurgitation and dilated right ventricular (RV) or tricuspid annulus, but minimal pulmonary hypertension (PH) regardless of RV systolic function. TAVR alone is appropriate for patients at high surgical risk with severe secondary tricuspid regurgitation and dilated RV or tricuspid annulus, with severe PH and moderate to severe RV dysfunction; in the same patients, SAVR plus tricuspid valve surgery may be appropriate.

SAVR plus ascending aorta repair is appropriate for patients with bicuspid valve and an ascending aorta of at least 4.5 cm at low, intermediate, or high surgical risk; SAVR alone is appropriate for patients with bicuspid valve and an ascending aorta of less than 4.5 cm at low, intermediate, or high surgical risk; TAVR alone may be appropriate in patients with bicuspid valve at high surgical risk regardless of the aorta size.

SAVR plus myectomy is appropriate and SAVR alone may be appropriate for patients with prominent basal septal hypertrophy with outflow tract narrowing and flow acceleration at low, intermediate, or high surgical risk; TAVR alone may be appropriate for patients at high or intermediate surgical risk.

Severe or critical aortic stenosis and major noncardiac surgery

For symptomatic patients with severe aortic stenosis undergoing elective or urgent major noncardiac surgery, aortic valve intervention is appropriate, and BAV may be considered.

For asymptomatic patients with severe aortic stenosis and no evidence of LV decompensation undergoing elective major noncardiac surgery, aortic valve intervention is appropriate, and no intervention may be considered.

For asymptomatic patients with severe aortic stenosis and no evidence of LV decompensation undergoing urgent major noncardiac surgery, aortic valve intervention, no intervention, or BAV may be considered.

Aortic bioprosthesis with structural valve degeneration and severe symptomatic aortic stenosis or aortic regurgitation

SAVR or TAVR is appropriate in patients at intermediate or high surgical risk and a bioprosthesis size of at least 23 mm.

SAVR is appropriate and TAVR may be appropriate in the following patients:

  • Those at intermediate or high surgical risk and a bioprosthesis size of 21 mm
  • Those at high surgical risk and a bioprosthesis size up to 19 mm

SAVR is appropriate (and TAVR is not appropriate) in patients at intermediate risk and a bioprosthesis size up to 19 mm.


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