What is the role of B-type natriuretic peptide (BNP) measurement in the evaluation of aortic stenosis (AS)?

Updated: May 07, 2019
  • Author: Xiushui (Mike) Ren, MD; Chief Editor: Terrence X O'Brien, MD, MS, FACC  more...
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Answer

B-type natriuretic peptide (BNP) may provide incremental prognostic information in predicting symptom onset in asymptomatic patients with severe aortic stenosis. [2] A high or steadily rising BNP may predict the short-term need for valve replacement in asymptomatic, severe aortic stenosis. Preoperative BNP provides prognostic information on postoperative outcome. [26]

In evaluating data from a Japanese multicenter registry comprising 3815 patients with severe aortic stenosis, investigators assessed BNP levels in the 387 patients who had asymptomatic severe aortic stenosis with normal left ventricular ejection fraction and who were not referred for aortic valve replacement. [3] They found that increased BNP levels were associated with a greater risk for aortic stenosis-related adverse events (aortic valve-related death or heart failure hospitalization) in these patients, whereas there was a relatively low event rate in asymptomatic patients with BNP levels below 100 pg/mL. [3]

Go to Natriuretic Peptides in Congestive Heart Failure for more complete information on this topic.


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