What is the history of heart failure in patients with aortic stenosis (AS)?

Updated: May 07, 2019
  • Author: Xiushui (Mike) Ren, MD; Chief Editor: Terrence X O'Brien, MD, MS, FACC  more...
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Answer

Heart failure symptoms (ie, paroxysmal nocturnal dyspnea, orthopnea, dyspnea on exertion, and shortness of breath) may be due to systolic dysfunction from afterload mismatch, ischemia, or a separate cardiomyopathic process. Alternatively, diastolic dysfunction from LV hypertrophy or ischemia may also result in heart failure symptoms.

Results from the Simvastatin Ezetimibe in Aortic Stenosis (SEAS) study revealed that in patients with aortic stenosis without diabetes or known renal or cardiovascular disease, persistent or new-onset asymmetric interventricular septum hypertrophy was associated with a higher incidence of ischemic cardiovascular events than in those without asymmetric interventricular septum hypertrophy. [17]


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