When is percutaneous liver biopsy indicated?

Updated: Nov 21, 2019
  • Author: Gaurav Arora, MD, MS; Chief Editor: Kurt E Roberts, MD  more...
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Indications related to initial diagnosis include the following:

Indications related to surveiilance during treatment include the following:

  • Follow-up evaluation while on antiviral treatment for chronic hepatitis C (rare)
  • Monitoring of disease activity of autoimmune hepatitis during treatment (may assist in determining if therapy can be discontinued)

Indications relevant to the patient who has undergone a liver transplant include the following:

  • Diagnosis of acute cellular rejection
  • Diagnosis of chronic rejection
  • Diagnosis of recurrent hepatitis C
  • Diagnosis of cytomegalovirus (CMV) hepatitis
  • Protocol biopsies to monitor for fibrosis or inflammation (particularly in patients who received liver transplants to treat liver failure in chronic hepatitis C)

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