What are the NCCN guidelines on the treatment of low-risk acute promyelocytic leukemia (APL)?

Updated: May 03, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

For patients who are at low risk, NCCN lists the following regimens [14] :

  • All-trans-retinoic acid (ATRA), 45 mg/min divided doses daily until clinical remission, plus arsenic trioxide (ATO), 0.15 mg/kg IV daily until bone marrow remission (recommended)

  • ATRA plus daunorubicin (50 mg/m2 x 4 days or 60 mg/m2 x 3 days) and cytarabine (200 mg/m2 x 7 days)

  • ATRA plus idarubicin (12 mg/m2 on days 2, 4, 6, and 8)

  • ATRA plus ATO (0.3 mg/kg IV on days 1–5 of cycle one and 0.25 mg/kg twice weekly in weeks 2–8 or until clinical remission)

The NCCN recommends continuing induction therapy until count recovery occurs, then proceeding to consolidation therapy. 


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