What are the NCCN guidelines on the diagnosis of acute promyelocytic leukemia (APL)?

Updated: May 03, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

According to NCCN, multidisciplinary testing (immonohistochemistry, cytochemistry and molecular genetic analysis) are needed to diagnosis of APL in accordance with the 2016 WHO classification system. An APL diagnosis requires APL morphology and either:

  • t(15:17) by cytogenetics, or
  • Promelocytic leukemia (PML)/retinoic acid receptor alpha (RARA) by molecular testing

Patients are further classified as low risk (WBC ≤10,000/μL) or high risk (WBC >10,000/μL) [14] .


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