How is acute promyelocytic leukemia (APL) treated in elderly patients?

Updated: May 03, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Answer

Although APL in patients older than 60 years is sensitive to chemotherapy, these patients have higher death rates in complete remission. [43, 44] The PETHEMA group omitted one dose of idarubicin for induction chemotherapy in patients older than age 70 years. In the European APL93 trial, 18.6% of elderly patients with APL died, mainly from sepsis, during consolidation or maintenance treatment.

Although these patients can be treated with ATRA and a less intensive dose of chemotherapy, the consolidation regimen should be altered to liposomal ATRA or ATO. These drugs can also be used in combination.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!