What is the role of intrathecal chemotherapy in the treatment of acute promyelocytic leukemia (APL)?

Updated: May 03, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

In patients who have central nervous system (CNS) involvement or who are at higher risk for CNS relapse, intrathecal chemotherapy is usually given in five doses. The regimen is a combination of cytarabine (50 mg), methotrexate (15 mg), and hydrocortisone (30 mg), given weekly for 5 weeks. For prophylaxis, one dose is given during induction, and four doses are given during consolidation. [42]


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