What is the risk stratification for acute promyelocytic leukemia (APL)?

Updated: May 03, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Prognostic factors were identified in 2000 by the Italian Group for Adult Hematologic Diseases (GINEMA) and Spanish PETHEMA group in a 217-patient multivariate analysis. [26] These researchers proposed risk stratification based on WBC and platelet count, as follows:

  • Low risk - WBC < 10,000/μL and platelets >40,000/μL

  • Intermediate risk - WBC < 10,000/μL and platelets < 40,000/μL

  • High risk - WBC >10,000/μL and platelets < 40,000/μL


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