What are the signs and symptoms of acute promyelocytic leukemia (APL)?

Updated: May 03, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Most of the signs and symptoms of acute promyelocytic leukemia (APL) are also seen in cases of acute myelogenous leukemia (AML). These include the following:

  • Fatigue, weakness, and dyspnea related to anemia

  • Easy bruising or bleeding caused by thrombocytopenia or coagulopathy

  • Fever and infection related to leukopenia

Most patients with APL present with pancytopenia. About 10-30% of patients present with leukocytosis. [18]


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