What is the role of WBC count in determining the prognosis of acute promyelocytic leukemia (APL)?

Updated: May 03, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The white blood cell (WBC) count is viewed as an important index associated with prognosis in APL. The National Comprehensive Cancer Network (NCCN) uses WBC counts to classify patients as either low risk (WBC ≤10,000/μL) or high risk (WBC >10,000/μL). [14] In addition to higher WBC counts, the following have also been identified as risk factors for early death [13, 12] :

  • Increased serum creatinine level
  • Older age
  • Male sex
  • Elevated fibrinogen level

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