What is the prognosis of acute promyelocytic leukemia (APL)?

Updated: May 03, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Unlike most leukemias, acute promyelocytic leukemia (APL) has a very good prognosis, with long-term survival rates up to 90% following treatment. [10]  However, the incidence of early death remains high, with 29% of APL patients dying within 30 days of their diagnosis; in 35% of those early deaths, the patient never received all-trans retinoic acid (ATRA) therapy. [11] The most common causes of early death in APL are hemorrhage, differentiation syndrome (DS), and infection. [12, 13]


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