What is the prevalence of acute promyelocytic leukemia (APL)?

Updated: May 03, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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In the United States, acute promyelocytic leukemia (APL) accounts for 5-15% of all adult leukemias. [7] Approximately 30,800 cases of acute leukemia are diagnosed yearly in the US, and about 1000 of those are APL. The annual incidence of APL in Italy is approximately 0.6 per 1 million people.

Douer noted that the APL-specific PML/RARA gene rearrangement is different in Latinos and non-Latinos, and that the incidence rate of  APL is higher in patients originating in Latin America. [8]  In contrast, Matasar et al reported that lifetime incidence rates of APL were not higher in US Hispanics than in whites, but the age distribution among Hispanics was significantly different from that in non-Hispanic whites, with greater incidence rates for children ages 1-19 years and adults ages 20-44 years. Blacks had lower lifetime incidence rates than non-Hispanic whites, Hispanics, and Asians. [9]

The incidence of APL in males and females is equal. [8] The median age of onset of APL is about age 40 years.

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