What is the role of dietary supplements in the prevention of preeclampsia?

Updated: Nov 29, 2018
  • Author: Kee-Hak Lim, MD; Chief Editor: Ronald M Ramus, MD  more...
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Research into the use of calcium and vitamin C and E supplementations in low-risk populations did not find a reduction in the incidence of preeclampsia. [84, 85, 86] In a multicenter, randomized, controlled trial, Villar et al found that at the doses used for supplementation, vitamins C and E were not associated with a reduction of preeclampsia, eclampsia, gestational hypertension, or any other maternal outcome. Low birthweight, small for gestational age, and perinatal deaths were also unaffected. [87]

A study by Vadillo-Ortega et al suggests that in a high-risk population, supplementation during pregnancy with a special food (eg, bars) containing L-arginine and antioxidant vitamins may reduce the risk of preeclampsia. However, antioxidant vitamins alone do not protect against preeclampsia. More studies performed on low-risk populations are needed. [88]

Results from the Norwegian Mother and Child Cohort Study suggest that supplementation of milk-based probiotics may reduce the risk of preeclampsia in primiparous women. A prospective randomized trial has not yet been done to evaluate this intervention. [89]

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