Which abnormal lab results should increases suspicion of preeclampsia?

Updated: Nov 29, 2018
  • Author: Kee-Hak Lim, MD; Chief Editor: Ronald M Ramus, MD  more...
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Answer

Answer

Other laboratory values suggestive of preeclampsia include an elevation in hematocrit and a rise in serum creatinine and/or uric acid. A decreased level of placental growth factor (PlGF) in the blood is also suggestive of preeclampsia. [54, 55] Although these laboratory abnormalities increase the suspicion for preeclampsia, none of these laboratory tests should be used to diagnose preeclampsia.

In a study of 540 women with type 1 diabetes, Holmes and colleagues found that those women who developed preeclampsia had abnormal serum levels of angiogenic and antiangiogenic compounds in the second trimester. At 26 weeks’ gestation, women who later developed preeclampsia had significantly lower levels of the angiogenic factor PlGF, significantly higher levels of the antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), as well as alteration in the ratio of PlGF to sEng or the ratio of sFlt-1 to PlGF. [56, 57]


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