How do the risk factors for early-onset and late-onset preeclampsia vary?

Updated: Nov 29, 2018
  • Author: Kee-Hak Lim, MD; Chief Editor: Ronald M Ramus, MD  more...
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Answer

An analysis of 456,668 singleton births found that early-onset (< 34 weeks' gestation) and late-onset (≥34 weeks' gestation) preeclampsia shared some etiologic features, but their risk factors and outcomes differed. Shared risk factors for early- and late-onset preeclampsia included older maternal age, Hispanic race, Native American race, smoking, unmarried status, and male fetus. Risk factors more strongly associated with early-onset preeclampsia than late-onset disease included black race, chronic hypertension, and congenital anomalies, while younger maternal age, nulliparity, and diabetes mellitus were more strongly associated with late-onset preeclampsia than with early-onset disease. [41, 42]


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