What is the role of genetics in the pathogenesis of preeclampsia?

Updated: Nov 29, 2018
  • Author: Kee-Hak Lim, MD; Chief Editor: Ronald M Ramus, MD  more...
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Answer

Answer

Preeclampsia has been shown to involve multiple genes. Over 100 maternal and paternal genes have been studied for their association with preeclampsia, including those known to play a role in vascular diseases, BP regulation, diabetes, and immunologic functions.

Importantly, the risk of preeclampsia is positively correlated between close relatives; a study showed that 20-40% of daughters and 11-37% of sisters of women with preeclampsia also developed the disease. [21] Twin studies have shown a high correlation as well, approaching 40%.

Because preeclampsia is a genetically and phenotypically complex disease, it is unlikely that any single gene will be shown to play a dominant role in its development.


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