Which circulating proangiogenic factors are decreased in women with preeclampsia?

Updated: Nov 29, 2018
  • Author: Kee-Hak Lim, MD; Chief Editor: Ronald M Ramus, MD  more...
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In another investigation, Maynard et al observed that the serum levels of VEGF and PlGF were decreased in women with preeclampsia. [29] However, the magnitude of decrease was less pronounced for VEGF, as its serum level was not as high as that of PlGF, even in normal pregnancy. Other investigators have confirmed this finding and have shown that the serum level of PlGF decreased in women before they developed preeclampsia. [30, 31]

Bills et al suggest that circulating VEGF-A levels in preeclampsia are biologically active because of a loss of repression of VEGF-receptor 1 signaling by PlGF-1, and VEGF165 b may be involved in the increased vascular permeability of preeclampsia. [32]

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