What is the role of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in the pathogenesis of preeclampsia?

Updated: Nov 29, 2018
  • Author: Kee-Hak Lim, MD; Chief Editor: Ronald M Ramus, MD  more...
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Answer

Answer

VEGF and PlGF promote angiogenesis by interacting with the VEGF receptor family. Although both growth factors are produced by placenta, the serum level of PlGF rises much more significantly in pregnancy. In a study, Taylor et al demonstrated that the serum level of PlGF decreased in women who later developed preeclampsia. [28] The fall in serum level was notable as early as the second trimester in women who developed preeclampsia and intrauterine growth restriction.


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