What is the role of ventilation-perfusion scanning in the diagnosis of pulmonary veno-occlusive disease (PVOD)?

Updated: Oct 16, 2018
  • Author: Hakim Azfar Ali, MD; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

In patients with pulmonary veno-occlusive disease (PVOD), abnormal ventilation-perfusion scan findings are not unusual. The scan may reveal focal areas of hypoperfusion, which may lead to a misdiagnosis of chronic thromboembolic pulmonary hypertension. A high-probability ventilation-perfusion scan in a patient with pulmonary hypertension does not always indicate a proximal pulmonary arterial process.

The reported ventilation-perfusion scan findings have also included (1) diffuse, patchy distribution of tracer material without clear segmental or subsegmental defects and (2) a unilateral absence of perfusion due to severe, asymmetrical involvement. The type of defect may vary depending on the size and location of the involved veins. [45]


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