What is the role of radiation exposure in the etiology of pulmonary veno-occlusive disease (PVOD)?

Updated: Oct 16, 2018
  • Author: Hakim Azfar Ali, MD; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Radiation exposure is a well-recognized cause of vascular injury. A case of PVOD that may be associated with previous mantle irradiation for Hodgkin lymphoma has been reported. [25] However, the presence of a prothrombotic state in malignancies, especially in adenocarcinomas, simultaneously with exposure to chemotherapeutic agents and radiotherapy precludes the establishment of a firm cause-and-effect relationship between malignancy and PVOD.


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