What are the genetic causes of pulmonary veno-occlusive disease (PVOD)?

Updated: Oct 16, 2018
  • Author: Hakim Azfar Ali, MD; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Several cases of PVOD have been reported to occur in siblings, with a similar age of onset. [17, 18] These observations may indicate a genetic predisposition or common environmental exposures. A case of well-documented PVOD associated with a bone morphogenetic protein receptor protein type II (BMPR2) mutation has been reported suggesting a possible pathogenetic connection with idiopathic PAH or heritable PAH. [19]


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