What causes pulmonary veno-occlusive disease (PVOD)?

Updated: Oct 16, 2018
  • Author: Hakim Azfar Ali, MD; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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The exact etiology of pulmonary veno-occlusive disease (PVOD) remains largely unknown. However, several indirect observations have led to many hypotheses regarding the etiology. One such hypothesis proposes that injury to the vessel walls leads to a cascade of humoral and mechanical events that eventually results in structural changes with the end result being widespread fibrotic venous constriction or occlusion. [9]

The following mechanisms for injury have been proposed:

  • Immune mediated

  • Infectious

  • Genetic

  • Toxic

  • Radiologic

  • Coagulopathic

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