Which medications in the drug class Urate-Oxidase Enzymes are used in the treatment of Burkitt Lymphoma and Burkitt-like Lymphoma?

Updated: Dec 20, 2019
  • Author: Ali H Kanbar, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Urate-Oxidase Enzymes

Urate-oxidase enzymes can be used to treat hyperuricemia associated with malignancy.

Rasburicase (Elitek)

Rasburicase is a recombinant form (derived from Saccharomyces cervisiae-synthesized, Aspergillus flavus) of the enzyme urate oxidase, which oxidizes uric acid to allantoin. This agent is indicated for the treatment and prophylaxis of severe hyperuricemia associated with the treatment of malignancy and has an elimination half-life of 18 hours. Hyperuricemia causes a precipitant in the kidneys, which leads to acute renal failure. Unlike uric acid, allantoin is soluble and easily excreted by the kidneys.


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