What is the IVAC regimen for the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Updated: Dec 20, 2019
  • Author: Ali H Kanbar, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The IVAC regimen is as follows:

  • Ifosfamide 1500 mg/m2 IV on days 1-5, with mesna protection

  • Etoposide 60 mg/m2 IV on days 1-5

  • Cytarabine 2 g/m2 IV every 12 hours on days 1-2

  • Intrathecal methotrexate 12 mg (patient older than age 3 y) on day 5

Administration of colony-stimulating factors is usually started 24 hours after completion of chemotherapy and continues until the ANC >1000/μL. See the Absolute Neutrophil Count calculator.


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