What is the CODOX-M regimen for the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Updated: Dec 20, 2019
  • Author: Ali H Kanbar, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Answer

The CODOX-M regimen is as follows:

  • Cyclophosphamide 800mg/m2 IV on day 1, followed by 200 mg/m2 IV on days 2-5

  • Doxorubicin 40 mg/m2 IV on day 1

  • Vincristine 1.5 mg/m2 IV (no capping of dose) on days 1 and 8 (cycle 1), as well as on days 1, 8, and 15 (cycle 3)

  • Methotrexate 1200 mg/m2 IV over 1 hour on day 10; then 240 mg/m2/h for the next 23 hours; leucovorin rescue begins 36 hours from the start of the methotrexate infusion

  • Intrathecal cytarabine 70 mg (patient older than age 3 y) on days 1 and 3

  • Intrathecal methotrexate 12 mg (patient older than age 3 y) on day 15


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!