How is Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL) treated?

Updated: Dec 20, 2019
  • Author: Ali H Kanbar, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Burkitt lymphoma (BL) is a very fast growing tumor. Patients should be admitted to the hospital for rapid workup and diagnostic measures. Chemotherapy is the mainstay of treatment for this disease; consultation with a hematologist and oncologist should be obtained as soon as possible. No role exists for surgery or radiation therapy in the treatment of Burkitt lymphomaL).

It is critical to closely monitor serum chemistries in patients with Burkitt lymphoma (BL), especially during chemotherapy because of the high risk of tumor lysis syndrome and uric acid nephropathy. Prophylactic allopurinol and aggressive hydration with urine alkalinization should be administered.

Intravenous antibiotics should be administered for neutropenic fevers. Growth factors (granulocyte-macrophage colony-stimulating factor [GM-CSF] or granulocyte colony-stimulating factor [G-CSF]) are administered to help decrease the duration of neutropenia.

Transfusions (red blood cells or platelets) are administered as clinically indicated for anemia and thrombocytopenia. All blood products should be leukodepleted and irradiated.


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