What is the most commonly used staging system for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Updated: Dec 20, 2019
  • Author: Ali H Kanbar, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Ann Arbor system and St. Jude/Murphy staging (commonly used)

Stage I

  • Single tumor (extranodal)

  • Single anatomic area (nodal)

Stage II

  • Single tumor (extranodal) with regional node involvement

  • Primary gastrointestinal tumor

  • Lymphoma involving nodal areas on the same side of the diaphragm

Stage IIR

  • Completely resected intra-abdominal disease

Stage III

  • Lymphoma involving sites on opposite sides of the diaphragm

  • All primary intrathoracic tumors

  • All paraspinal or epidural tumors

  • Extensive intra-abdominal disease

Stage IV

  • Any of the above, with central nervous system (CNS) or bone marrow involvement (< 25%) at presentation

Around 30% of patients present with limited-stage disease (stage I or II), and 70% present with more extensive disease (stage III or IV). Bone marrow involvement is found in 30-38% of patients, and the CNS is involved in 13-17% of adult patients.


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