What is the prognosis of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL) in children?

Updated: Dec 20, 2019
  • Author: Ali H Kanbar, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The prognosis of Burkitt lymphoma (BL) in children correlates with the bulk of disease at the time of diagnosis, as outlined below. Before the advent of aggressive therapeutic programs, children with Burkitt lymphoma (BL) died rapidly. With appropriate management of the metabolic consequences of rapid cell turnover and with combination chemotherapy and central nervous system (CNS) prophylaxis, the survival rate has been improved significantly (≤ 60%).

  • Patients with limited (A, AR; stage I and II) disease have an excellent prognosis, with a survival rate greater than 90%

  • Patients with more extensive disease (stage III and IV), especially involvement of the bone marrow and CNS, have a worse prognosis, but long-term survival rates of 50-90% can be achieved with more aggressive chemotherapy regimens

  • Patients with relapse disease have a long-term survival rate of 20-50%

  • For those who experience relapse, as many as 25% of children may be able to achieve a long-term disease-free survival through high-dose therapy with autologous hematopoietic stem-cell transplantation (HSCT). [27] The addition of rituximab to this therapeutic regimen may further increase the response rate. [28]


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