What is Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Updated: Dec 20, 2019
  • Author: Ali H Kanbar, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Burkitt lymphoma, or small noncleaved cell lymphoma, is a highly aggressive B-cell non-Hodgkin lymphoma (NHL) characterized by the translocation and deregulation of the c-myc gene on chromosome 8. [1] The 2016 World Health Organization (WHO) classification of lymphoid neoplasms recognizes Burkitt-like lymphoma with 11q aberration as a new provisional entity that lacks MYC rearrangements but resembles Burkitt lymphoma morphologically, to a large extent phenotypically, and by gene expression profiling. [2] See the image below.

Computed tomography scan in a patient with a large Computed tomography scan in a patient with a large, left-sided axillary mass from which a biopsy was obtained. Biopsy findings were consistent with small noncleaved cell non-Hodgkin lymphoma.

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