What is the prevalence of cardiac disease in brief resolved unexplained event (BRUE) (apparent life-threatening event) (ALTE)?

Updated: Feb 28, 2019
  • Author: Patrick L Carolan, MD; Chief Editor: Girish D Sharma, MD, FCCP, FAAP  more...
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Hoki et al (2012) report an ALTE cohort followed longitudinally, revealing significant cardiac disease in less than 1% of patients. [17] Two patients were identified with significant cardiac disease (cardiomyopathy, ventricular pre-excitation). During 7.7 years of follow-up, 3 additional significant cardiac diagnoses (ventricular pre-excitation, frequent ventricular ectopy, moderate aortic stenosis) were identified. In this group, ECG was sensitive for identifying significant cardiac disease. In general, however, all cardiac tests had low positive predictive value. Significant cardiac disease was associated with prematurity (22% vs 80%, P =.002), but not age, sex, prior ALTE, or rescue breaths.

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