What is the role of synthetic psoralen in the prevention of transfusion-transmitted diseases?

Updated: Jan 15, 2017
  • Author: Mudassar Zia, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

Amotosalen is a synthetic psoralen that acts after exposure to ultraviolet (UV) light to form cross-links in nucleic acid chains and stop the multiplication of pathogens. This method inactivates almost all of the currently screened agents (eg, HIV, HAV, T cruzi, gram-negative rods), including enveloped and nonenveloped viruses, bacteria, and protozoa. The drawback to synthetic psoralen is a reduction in platelet activity, thus requiring more frequent platelet transfusions. [86, 87, 88, 89, 90]


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