How is transfusion-transmitted West Nile virus (WNV) infection prevented?

Updated: Jan 15, 2017
  • Author: Mudassar Zia, MD; Chief Editor: Emmanuel C Besa, MD  more...
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The current strategy to break the chain of WNV transmission via blood is NAT. An intriguing situation is the high risk of residual transmission in some early phase viremic patients. Thus, NAT is used on individual donor samples (ie, individual donation nucleic acid testing [ID-NAT], instead of pool testing [ie, MP-NAT]) to detect these low-level viremic patients. This is especially useful to interdict transmission in the high-incidence season. For donors who are detected as positive for WNV infection, the US Food and Drug Administration (FDA) recommends deferral for at least 120 days. [41, 42, 43, 44]

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