How is transfusion-transmitted HCV infection prevented?

Updated: Jan 15, 2017
  • Author: Mudassar Zia, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Detection of HCV infection by MP-NAT is the standard of care in the United States for the detection of the viral RNA. The HCV MP-NAT has reduced the window period for the detection of infection by 80-90% when compared with HCV testing by detection of antibodies. [21]

The use of the polymerase chain reaction (PCR) assay has reduced the risk of acquiring HCV from blood transfusions to 1 in 230,000 donations. The newer assays have decreased the window period after infection to 1-2 weeks. Hepatitis C–positive donors are permanently deferred from blood donations.

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