What actions should be immediately taken when transfusion-transmitted bacterial infections (TTBIs)?

Updated: Jan 15, 2017
  • Author: Mudassar Zia, MD; Chief Editor: Emmanuel C Besa, MD  more...
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As soon as TTBI is suspected, the following course of action should be taken:

  • Stop the transfusion

  • Aggressively hydrate and resuscitate the patient

  • Make sure the symptoms are not due to a mismatched blood product resulting from a clerical error, and make the blood bank aware of the possibility of an infection; the blood product should be sent for a culture and Gram stain in an attempt to confirm TTBI and to isolate bacteria

  • Repeat the type and cross-match, and also collect blood for a Coombs test and bacterial culture from the recipient

  • The patient should be started on empiric parenteral antibiotics until isolation of an agent is available to help in narrowing down the antibiotic coverage

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