What is the role of cytokines in the pathogenesis of anemia of chronic disease and renal failure?

Updated: Apr 13, 2020
  • Author: Gates B Colbert, MD, FASN; Chief Editor: Emmanuel C Besa, MD  more...
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Another proposed mechanism for anemia of chronic illness involves cytokines, such as interleukins (IL-1 and IL-6), and tumor necrosis factor (TNF-alpha), which are believed to cause the destruction of RBC precursors and decrease the number of erythropoietin receptors on progenitor cells.

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