How is the type 2 (T2 high) subtype of asthma?

Updated: Oct 07, 2019
  • Author: John J Oppenheimer, MD; Chief Editor: Michael A Kaliner, MD  more...
  • Print


In the past decade there have been significant advances in the phenotypic classification of asthma. Asthma can be viewed as a Type 2 (T2 high) subtype, which implicates signaling of IL-4, IL-13, Il-5, IgE and other inflammatory cascade pathways. Proposed biomarkers of T2 asthma include serum IgE, blood and lung eosinophils, exhaled nitric oxide, and others.  Allergic asthma is considered a T2-high form of asthma. Less is known about non-T2 asthma, but it is marked by the absence of these biomarkers. Asthma can also be broadly categorized as eosinophilic versus non-eosinophilic. Asthmatics with eosinophilic disease may have very high levels of eosinophils in the blood and/or sputum. Asthma-COPD Overlap (ACO) is also an overlap phenotype seen in patients with clinical features of both asthma and COPD.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!