Which medications in the drug class Leukotriene Receptor Antagonist are used in the treatment of Acute Urticaria?

Updated: Mar 21, 2018
  • Author: Henry K Wong, MD, PhD; Chief Editor: Michael A Kaliner, MD  more...
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Leukotriene Receptor Antagonist

In recent years, leukotriene receptor antagonists (eg, montelukast) have been added to antihistamines to control urticaria. These can be used as third-line agents as there is only weak evidence to support their use in acute urticaria.

Montelukast (Singulair)

Montelukast is a potent and selective antagonist of leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1. It prevents or reverses some of the pathologic features associated with the inflammatory process mediated by leukotrienes C4, D4, and E4. It is available as a tablet, chewable tablet, or PO granules. Granules may be administered directly in the mouth or dissolved in 1 tsp of cold or room-temperature baby formula, breast milk, or food (stable with applesauce, carrots, rice, or ice cream).

Zafirlukast (Accolate)

Zafirlukast inhibits the effects by leukotriene receptors, whose activity has been associated with airway edema, smooth muscle contraction, and cellular activity associated with the symptoms.

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