What is the role of skin biopsy in the evaluation of acute urticaria (hives)?

Updated: Mar 21, 2018
  • Author: Henry K Wong, MD, PhD; Chief Editor: Michael A Kaliner, MD  more...
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A diagnostic skin biopsy is not helpful but should be considered if lesions do not resolve in patients suspected of having urticarial vasculitis (eg, in patients who present with features such as fever, painful lesions, arthralgia, elevated erythroid segmentation rate, lesions that last 24 hours or longer, or lesions that resolve with residual petechiae or purpura). [30, 46]

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