What are medical causes of recurrent acute urticaria (hives)?

Updated: Mar 21, 2018
  • Author: Henry K Wong, MD, PhD; Chief Editor: Michael A Kaliner, MD  more...
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Other medical causes of recurrent urticaria include the following:

  • Cryoglobulinemias (eg, associated with hepatitis C, chronic lymphocytic leukemia)

  • Serum sickness

  • Other immune complex–mediated inflammation

  • Systemic lupus erythematosus, rheumatoid arthritis, juvenile rheumatoid arthritis, or other rheumatologic diseases (rare causes of urticaria)

  • Hypothyroidism and hyperthyroidism, although euthyroid patients with antithyroid antibodies (ie, vide infra) can be affected [19]

  • Lymphoreticular malignancies (eg, chronic lymphocytic leukemia)

  • Pregnancy (ie, pruritic urticarial papules and plaques of pregnancy [PUPPP])

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