How is immunoglobulin A deficiency (IgAD) prevented?

Updated: May 15, 2018
  • Author: Marina Y Dolina, MD; Chief Editor: Michael A Kaliner, MD  more...
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See the list below:

  • Primary prevention for immunoglobulin A deficiency (IgAD) has not been developed. If a medication is under consideration as the cause of the IgAD, it should be discontinued.

  • Secondary prevention relies primarily on vaccination to increase specific IgG and IgM (see Medication). In situations in which purified and decontaminated water cannot be guaranteed, precautions such as boiling drinking water may help prevent GI infections like giardiasis or cryptosporidiosis. The role of prophylactic antibiotics is controversial because they may increase the hazard of infection with resistant bacteria or fungi.

  • Tertiary prevention includes (1) prompt antibiotic treatment for respiratory tract infections, (2) microbial identification of diarrheal pathogens and specific treatment, (3) dietary modification for malabsorption syndromes, and (4) use of washed cells and/or IgA-poor blood if whole blood is needed, and screening for anti-IgA antibodies if reactions to blood products occur (not routinely performed).

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