What is the role of biopsy in the workup of immunoglobulin A deficiency (IgAD)?

Updated: May 15, 2018
  • Author: Marina Y Dolina, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

Jejunal biopsy specimens of patients with IgAD who have chronic diarrhea and malabsorption may show blunting of the villi. IgM-secreting plasma cells are observed in the lamina propria, instead of IgA-secreting plasma cells. Otherwise, lymph node architecture is normal.


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