What is the role of imaging studies in the workup of immunoglobulin A deficiency (IgAD)?

Updated: May 15, 2018
  • Author: Marina Y Dolina, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

See the list below:

  • Perform chest radiography together with CT scans of the sinuses to investigate for structural lesions or chronic disease, and perform CT scans of the chest for a sensitive assessment of possible bronchiectasis.

    • In patients with primary humoral immunodeficiency and chronic productive cough, high-resolution computed tomography (HRCT) is helpful in evaluating the extent of lung damage. [78]

    • In a Mayo Clinic series, 95% of 50 patients with a late onset of adult hypogammaglobulinemia had grossly abnormal findings on sinus films but did not necessarily have symptoms of purulent sinusitis. [79]

    • In Denver, Colo, 28 (98%) of 30 patients had abnormal sinus films. [80]

    • Remember that patients with ataxia-telangiectasia and other DNA processing/repair enzyme defects are particularly prone to radiation-induced malignancies. Try to minimize radiographic studies in these individuals.

  • Patients who are first diagnosed with immunodeficiency when they are older than 45 years should undergo serum protein electrophoresis and an imaging study to rule out thymoma


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