What is the role of benzene in the etiology of immunoglobulin A deficiency (IgAD)?

Updated: May 15, 2018
  • Author: Marina Y Dolina, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

Occupational exposure to benzene: Workers maintaining cargo tanks that contain crude oil residues were exposed to benzene, as documented by blood and urine samples and exposure measurements. Tank workers showed a decline in IgA from baseline to pre-next shift, with suppression correlating with benzene concentrations in blood and urine and time spent in the tank. Declines in IgM and CD4 T cells were also noted. [75]


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