How does the prevalence of immunoglobulin A deficiency (IgAD) vary by age?

Updated: May 15, 2018
  • Author: Marina Y Dolina, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

This disease can be diagnosed in persons of any age.

Average serum IgA levels increase 0.2 ±0.06 g/L per decade of life. [40]

  • Those older than 6 months who have recurrent upper and lower respiratory tract infections with encapsulated bacteria (eg, H influenzae, S pneumoniae) should be evaluated for IgAD as well for specific IgG antibody deficiency, although these may be maturational delays rather than fixed defects. Patients with humoral deficiencies do not usually present with recurrent infections in the first few months of life because they have circulating IgG from placental transfer.

  • Children and adults may present with recurrent sinopulmonary infections or GI infections or diseases. Case reports exist of severe life-threatening infections in patients with SIgAD. [67, 68, 69]


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