Which GI conditions are associated with immunoglobulin A deficiency (IgAD)?

Updated: May 15, 2018
  • Author: Marina Y Dolina, MD; Chief Editor: Michael A Kaliner, MD  more...
  • Print
Answer

GI tract infections, including chronic or recurrent giardiasis and other disorders, are reported with increased frequency. Patients with SIgAD have a 10-fold increased risk of celiac disease. Milk intolerance is common in patients with primary IgAD. Reports indicate that patients with IgAD may have IgG antibodies against cow milk and ruminant serum proteins. Patients with high titers of antibodies to cow milk reportedly are more likely to have other autoantibodies. [61] A patient with SIgAD may still mainfest IgA antibody against select targets, such as transglutaminase and endomysium, as reported in one case of celiac disease in which IgG-specific antibodies were negative. [62]

Other conditions, such as ulcerative colitis, inflammatory bowel disease, Crohn disease, and pernicious anemia, have been described in IgA-deficient individuals. Friman et al showed that individuals with SIgAD have an increased risk of becoming a carrier of E coli strains that have increased proinflammatory properties, and hypothesize that this may contribute to the development of gastrointestinal disorders in SIgAD patients. [63] Mucosal infections include acute diarrhea caused by viruses, bacteria, or Giardia lamblia parasites. A higher occurrence of serum antibodies to milk antigens in patients with IgAD suggests that normal serum IgA responses protect the host from continuing exposure to environmental antigens.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!