What is the prognosis of hypogammaglobulinemia?

Updated: Dec 26, 2018
  • Author: Elizabeth A Secord, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

See the list below:

  • Prognosis has improved significantly since the introduction of IVIG therapy to routine practice.

    • Mortality due to overwhelming infections remains a major risk for these patients, although chronic progressive morbidity is more likely.

    • Chronic lung and liver diseases result in significant morbidity and mortality.

    • The risk of malignancy, especially lymphomas involving mucosal-associated lymphoid tissue, must be kept in mind.

    • For those who survive long enough, autoimmune diseases and cancers become a serious threat because the incidence of these diseases is several-fold higher in these patients than in matched controls. [4]

    • SCID is a true pediatric emergency that may not be apparent on the newborn physical examination. [1] Patients do not survive beyond childhood unless a definitive treatment is performed. However, if hematopoietic stem cell transplantation is performed a bone within the first 3 months of life, the chance of survival is approximately 93%.


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