How is hypogammaglobulinemia with normal-quality antibody response treated?

Updated: Dec 26, 2018
  • Author: Elizabeth A Secord, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

This group includes transient hypogammaglobulinemia of infancy (THI). In patients with THI the IgG levels are lower than age specific normal during infancy and early childhood with or without lower IgM, IgA levels but specific antibody response is preserved as well as an intact cellular immunity. The definitive diagnosis is made only after correction of the immunoglobulin levels. Antibiotics both for treatment and prophylaxis is the initial step and IgG administration is only considered with antibiotic failure or significant recurrent infections. Continued close monitoring for recovery and excluding other causes of hypogammaglobulinemia is important.


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