How is hypogammaglobulinemia with selective antibody deficiency treated?

Updated: Dec 26, 2018
  • Author: Elizabeth A Secord, MD; Chief Editor: Michael A Kaliner, MD  more...
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Answer

These patients have normal IgG levels are not hypogammaglobulinemia but have functional disorder with deficient response to polysaccharide antigen with pneumococcal vaccination pose a diagnostic and management challenge. IgRT is considered in settings of recurrent and severe infections, failure of antibiotics treatment or prophylaxis as a first line of treatment, complications of infections or antibiotics, impaired quality of life due to recurrent infections. Many of these patients’ particularly young children may require IgRT for limited time due to spontaneous recovery of responses to polysaccharide vaccine.


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