What is the role of blood product reactions in the etiology of hypogammaglobulinemia?

Updated: Dec 26, 2018
  • Author: Elizabeth A Secord, MD; Chief Editor: Michael A Kaliner, MD  more...
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History of anaphylaxis or other severe reactions following transfusion of blood products may indicate an underlying IgA deficiency, although this is controversial.

Rarely, patients with undetectable IgA antibodies may develop anti-IgA antibodies of the IgE isotype. Once sensitized, these patients may be at risk for anaphylactic reactions if they receive blood products containing IgA. Most patients who have anaphylactic reactions to blood transfusions, however, do not have IgA deficiency, and most patients with IgA deficiency do not develop IgE anti-IgA antibodies.

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